Many elderly persons face difficulties in administering conventional oral dosage forms because of hand tremors and disphagia. To fulfill these medical needs, a variety of dosage forms for oral administration known as intra-oral fast dissolving dosage forms were developed. Fast dissolving capsules are solid dosage forms which disintegrate or dissolve rapidly in the mouth without chewing and water. Novel fast dissolving capsules of amlodepine besylate were developed. Two preparation techniques were adopted namely laser perforation and vaccum drying. Nine formulae of amlodepine capsules were prepared, the powder blends of the drug and different excipients used were evaluated with respect to bulk density, tapped density and angle of repose. The prepared capsules were evaluated regarding their physical characteristics. In –vivo disintegration time was determined and in-vitro release study was also carried out to confirm that our goal was achieved. The prepared powder blends fulfilled the pharmacopeial limits. The two techniques proved to be promising and the in –vivo disintegration time of the prepared formulae ranged between 26- 37 seconds.
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